The Enrichment Center is required to remind you that the Weighted Companion Cube cannot talk. In the event that it does talk The Enrichment Centre asks you to ignore its advice.

GLaDOS: "Look, you're wasting your time. And, believe me, you don't have a whole lot left to waste. What's your point, anyway? Survival? Well, then, the last thing you want to do is hurt me. I have your brain scanned and permanently backed-up in case something terrible happens to you, which it's just about to. Don't believe me? Here, I'll put you on:"
Strange voice: Hellooooooooo!
GLaDOS: "That's you! That's how dumb you sound! You've been wrong about every single thing you've ever done, including this thing. You're not smart. You're not a scientist. You're not a doctor. You're not even a full-time employee! Where did your life go so wrong?"

This is your fault. I'm going to kill you. And all the cake is gone. You don't even care, do you?