Dr. Isiah Friedlander: Your son, James. He's a good kid?
Michael De Santa: He's a good kid? A good kid? Why? Does he help the fucking poor? No. He sits on his ass all day, smoking dope and jerking off while he plays that fucking game. If that's our standard for goodness... then no wonder this country's screwed.

Ortega: What the fuck, Trevor?
Trevor: This is the fuck, my soggy friend! You are out of business. The Lost MC are out of business. The guns and crank in this area go through Trevor Philips Enterprise, or they ain't going!

Have you read the manual for this thing?

I’m not stoned at all. Hell no, not at all. Completely not stoned. I’m completely not stoned. I’m straight. Completely straight. I could do anything. Shitt, I could be a brain surgeon. Brain surgery, I could do that. Uhh, I shoulda been a surgeon. That’s what I shoulda been…

Franklin: We're finna risk our lives to rob some motherfucking government killers again?
Michael: Yup.